When world-renowned Harvard symbologist Robert Langdon is summoned to a Swiss research facility to analyse a mysterious symbol seared into the chest of a murdered physicist, he discovers evidence of the unimaginable: the resurgence of an ancient secret brotherhood known as the Illuminati: a sinister and shadowy organisation that seek the destruction of their most hated enemy: the Catholic Church. Langdon's worst fears are confirmed on the eve of the Vatican's holy conclave, when a messenger of the Illuminati announces he has planted a bomb at the heart of Vatican City. With the countdown under way, Langdon jets to Rome to join forces with Vittoria Vetra, a beautiful and mysterious Italian scientist, to assist the Vatican in a desperate bid for survival. Embarking on a frantic hunt through sealed crypts, dangerous catacombs, deserted cathedrals, and even to the heart of the most secretive vault on earth, Langdon and Vetra follow a 400-year old trail of ancient symbols that snakes across Rome toward the long-forgotten Illuminati lair ... a secret location that contains the only hope for Vatican salvation